Workshop Proceeding

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine: Proceedings of a Workshop (2018)

An ad hoc planning committee will plan and conduct a public workshop to explore the potential of ongoing and future research in animal models with implications for precision medicine. This workshop will bring together experts on the use of state-of-the-art technologies and technological advances to explore:

-- How the design, creation, and analysis of current and next-generation animal models can inform the practice of precision medicine;
-- Reproducibility concepts to improve the clinical relevance of animal-based validation experiments and pre- and co-clinical trials in the context of precision medicine;
-- Welfare and regulatory considerations of current and especially next-generation animal models that would inform the design of targeted, personalized therapies.

According to the National Institutes of Heath. precision medicine "is an approach for disease treatment and prevention that takes into account individual differences in lifestyle, environment, and biology." During this two-day event, state-of-the-art animal-based research and its relevance to precision medicine were presented and discussed. The workshop's sessions explored ways with which in vivo "precision modeling," next-generation animal models, and phenotyping platforms can catalyze and accelerate the advent of precision medicine. Complementary in vitro and in silico approaches to advance the Three Rs and means to ensure reproducibility of methods and data were prominent features of the sessions and discussions.